Lost Connections Book Summary - Lost Connections Book explained in key points
Listen to the Intro
00:00

Lost Connections summary

Johann Hari

Uncovering the Real Causes of Depression – and the Unexpected Solutions

4.7 (265 ratings)
32 mins
Table of Contents

    Lost Connections
    summarized in 12 key ideas

    Audio & text in the Blinkist app
    Key idea 1 of 12

    Contrary to claims made by pharmaceutical corporations, depression is not the result of a chemical imbalance.

    The author, Johann Hari, was 18 years old when he took his first antidepressant medication, but by this time he’d already had years of experience with depression.

    Even as a young child, Hari had his fair share of moments alone in a room, weeping uncontrollably. He came to understand that he was experiencing the symptoms of depression. When he went to his doctor for treatment, his doctor explained that the cause of depression is a chemical imbalance in the brain, which can be alleviated with prescription antidepressants.

    For Hari, this meant taking Paxil, one of many drugs on the market classified as selective serotonin reuptake inhibitors (SSRIs), which claim to raise a person’s serotonin levels to that of a “normal,” non-depressed person.

    Like many patients taking SSRIs for the first time, Hari experienced some initial relief, but it didn’t last long. So his doctor upped the dosage, leading to another period of relief followed by a relapse into depression and yet another increase in the dosage.

    One thing Hari could be sure about was that Paxil was causing him to gain weight and sweat more than usual. Eventually, in his 30s, Hari was faced with the truth: After over a decade of Paxil, he was still depressed. Following this realization, he embarked on an extensive period of research on the topic of depression and antidepressants, and what he discovered was truly shocking.

    After speaking to a number of researchers, Hari found that there was little evidence to support the claim that a chemical imbalance causes depression, or that SSRIs are an effective treatment for everyone suffering with depression.

    In the mid-90s, Harvard professor Irving Kirsch began taking a close look at the research on antidepressants. What he found was that the clinical tests being published by pharmaceutical companies were routinely skewed in order to get their medications released.

    During the clinical testing for Prozac, for example, 245 patients were tested. But in the published results, only the 27 patients that experienced positive results were mentioned. As for Paxil, the unedited results of one clinical test showed that patients responded better to the placebo than to the actual medication.

    Kirsch also researched the claims of a link between depression and the neurochemical serotonin. He found the connection to be an “accident of history” whereby scientists had misinterpreted findings and pharmaceutical companies had latched onto this misinformation to sell drugs.

    As the University of London professor Joanna Moncrieff told Hari, when it comes to anxious and depressed brains, “There’s no evidence that there’s a chemical imbalance.”

    Want to see all full key ideas from Lost Connections?

    Key ideas in Lost Connections

    More knowledge in less time
    Read or listen
    Read or listen
    Get the key ideas from nonfiction bestsellers in minutes, not hours.
    Find your next read
    Find your next read
    Get book lists curated by experts and personalized recommendations.
    Shortcasts
    Shortcasts New
    We’ve teamed up with podcast creators to bring you key insights from podcasts.

    What is Lost Connections about?

    Lost Connections (2018) takes you on a historical and scientific journey that dispels many of the lingering myths surrounding depression and the reasons it touches so many of us. Along the way, author Johann Hari introduces readers to the cutting-edge advancements being made by those looking into new solutions for depression and anxiety.

    Best quote from Lost Connections

    The [pharmaceutical industry] is just sick and bought and corrupted, and I cant describe it otherwise. – Professor John Ioannidis, Stanford University

    —Johann Hari
    example alt text

    Who should read Lost Connections?

    • Students of psychology, mental health and social work
    • Readers experiencing depression and eager for solutions
    • Friends and loved ones of those with depression or anxiety

    About the Author

    Johann Hari is the New York Times best-selling author of Chasing the Scream (2015). He’s also well known for his TED Talk, “Everything You Think You Know About Addiction Is Wrong.”

    Categories with Lost Connections

    Books like Lost Connections

    People ❤️ Blinkist
    Sven O.

    It's highly addictive to get core insights on personally relevant topics without repetition or triviality. Added to that the apps ability to suggest kindred interests opens up a foundation of knowledge.

    Thi Viet Quynh N.

    Great app. Good selection of book summaries you can read or listen to while commuting. Instead of scrolling through your social media news feed, this is a much better way to spend your spare time in my opinion.

    Jonathan A.

    Life changing. The concept of being able to grasp a book's main point in such a short time truly opens multiple opportunities to grow every area of your life at a faster rate.

    Renee D.

    Great app. Addicting. Perfect for wait times, morning coffee, evening before bed. Extremely well written, thorough, easy to use.

    People also liked

    Start growing with Blinkist now
    26 Million
    Downloads on all platforms
    4.7 Stars
    Average ratings on iOS and Google Play
    91%
    Of Blinkist members create a better reading habit*
    *Based on survey data from Blinkist customers
    Powerful ideas from top nonfiction

    Try Blinkist to get the key ideas from 5,500+ bestselling nonfiction titles and podcasts. Listen or read in just 15 minutes.

    Start your free trial